Title : Shikonin inhibits adipogenesis by modulation of the WNT/β-catenin pathway.

Pub. Date : 2011 Feb 14

PMID : 21146546






1 Functional Relationships(s)
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1 Shikonin-induced reductions of the major transcription factors of adipogenesis including peroxisome proliferator-activated receptor gamma and CCAAT/enhancer binding protein alpha, and lipid metabolizing enzymes including fatty acid binding protein 4 and lipoprotein lipase, as well as intracellular fat accumulation, were all significantly recovered by siRNA-mediated knockdown of beta-catenin. shikonin peroxisome proliferator activated receptor gamma Mus musculus