Title : [Impact of cyclosporine A on the expression of T-bet, GATA-3, relevant signal transduction molecules, cytokine and Th1/Th2 balance in patients with chronic aplastic anemia].

Pub. Date : 2010 Oct

PMID : 21129263






3 Functional Relationships(s)
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1 After treating with CsA for 6 months of CsA treatment, expression of T-bet, STAT4, T-bet/GATA-3 ratio, Th1 proportion, IFN-gamma and IL-12 levels were lower than before, however, the expression of T-bet, STAT4, T-bet/GATA-3 ratio, Th1 proportion and IFN-gamma had not been reduced to normal state. Cyclosporine interferon gamma Homo sapiens
2 After treating with CsA for 6 months of CsA treatment, expression of T-bet, STAT4, T-bet/GATA-3 ratio, Th1 proportion, IFN-gamma and IL-12 levels were lower than before, however, the expression of T-bet, STAT4, T-bet/GATA-3 ratio, Th1 proportion and IFN-gamma had not been reduced to normal state. Cyclosporine interferon gamma Homo sapiens
3 CsA lowers the abnormal activation of IFN-gamma/T-bet and IL-12/STAT4 pathways to correct Th1 hyperpolarization, which may reduce the abnormally activated cell-mediated immunity and relax hematopoietic depression of AA patients. Cyclosporine interferon gamma Homo sapiens