Pub. Date : 2011 Feb
PMID : 21127402
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | zVAD also stimulated PARP activation, and the PARP inhibitor DPQ can reduce zVAD-induced cell death, but did not affect ROS production, suggesting the increased ROS leads to PARP activation and cell death. | benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone | poly (ADP-ribose) polymerase family, member 1 | Mus musculus |
| 2 | zVAD also stimulated PARP activation, and the PARP inhibitor DPQ can reduce zVAD-induced cell death, but did not affect ROS production, suggesting the increased ROS leads to PARP activation and cell death. | benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone | poly (ADP-ribose) polymerase family, member 1 | Mus musculus |
| 3 | zVAD also stimulated PARP activation, and the PARP inhibitor DPQ can reduce zVAD-induced cell death, but did not affect ROS production, suggesting the increased ROS leads to PARP activation and cell death. | benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone | poly (ADP-ribose) polymerase family, member 1 | Mus musculus |
| 4 | In conclusion, we confirm the autophagic death in zVAD-treated L929 cells, and define a new molecular pathway in which Src-dependent ERK and JNK activation can link a signal from caspase inhibition to autophagy, which in turn induce ROS production and PARP activation, eventually leading to necroptosis. | benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone | poly (ADP-ribose) polymerase family, member 1 | Mus musculus |