Pub. Date : 2011 Mar
PMID : 21123766
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | This study examined how HMG-CoAR inhibition by atorvastatin modulates expression of key genes involved in intestinal cholesterol metabolism. | Atorvastatin | 3-hydroxy-3-methylglutaryl-CoA reductase | Homo sapiens |
| 2 | Atorvastatin significantly increased intestinal mRNA levels of HMG-CoAR (59%), LDL receptor (LDLR) (52%), PCSK9 (187%), SREBP-2 (44%), and HNF-4alpha (13%). | Atorvastatin | 3-hydroxy-3-methylglutaryl-CoA reductase | Homo sapiens |
| 3 | These results indicate that HMG-CoAR inhibition with atorvastatin stimulates the intestinal expression of NPC1L1, LDLR, and PCSK9; increases cholesterol absorption; and reduces expression of ABCG5/8; these effects are most likely mediated by upregulation of the transcription factors SREBP-2 and HNF-4alpha. | Atorvastatin | 3-hydroxy-3-methylglutaryl-CoA reductase | Homo sapiens |