PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21123766-2	2011	This study examined how HMG-CoAR inhibition by atorvastatin modulates expression of key genes involved in intestinal cholesterol metabolism.	Atorvastatin	47-59	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	24-32	
21123766-6	2011	Atorvastatin significantly increased intestinal mRNA levels of HMG-CoAR (59%), LDL receptor (LDLR) (52%), PCSK9 (187%), SREBP-2 (44%), and HNF-4alpha (13%).	Atorvastatin	0-12	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	63-71	
21123766-9	2011	These results indicate that HMG-CoAR inhibition with atorvastatin stimulates the intestinal expression of NPC1L1, LDLR, and PCSK9; increases cholesterol absorption; and reduces expression of ABCG5/8; these effects are most likely mediated by upregulation of the transcription factors SREBP-2 and HNF-4alpha.	Atorvastatin	53-65	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	28-36