Pub. Date : 2007 Jun 20
PMID : 21118639
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | [The influence of arsenic trioxide combined with cisplatin on the growth and expression of X-linked inhibitor of apoptosis protein, XIAP of human non-small cell lung cancer cells]. | Arsenic Trioxide | X-linked inhibitor of apoptosis | Homo sapiens |
| 2 | The aim of this study is to investigate the influence of arsenic trioxide (As2O3) injection combined with cisplatin (DDP) on the growth, apoptosis and XIAP mRNA of human non-small cell lung cancer cell lines. | Arsenic Trioxide | X-linked inhibitor of apoptosis | Homo sapiens |
| 3 | The aim of this study is to investigate the influence of arsenic trioxide (As2O3) injection combined with cisplatin (DDP) on the growth, apoptosis and XIAP mRNA of human non-small cell lung cancer cell lines. | Arsenic Trioxide | X-linked inhibitor of apoptosis | Homo sapiens |
| 4 | XIAP mRNA level of the cells was detected by RT-PCR before and after treatment of As2O3 combined with DDP or without DDP. | Arsenic Trioxide | X-linked inhibitor of apoptosis | Homo sapiens |
| 5 | RESULTS: Compared to individual drug, As2O3 injection combined with DDP may obviously inhibit the proliferation of H460 cells, increase the apotosis rate of cells and strengthen inhibition of XIAP mRNA expression in cells. | Arsenic Trioxide | X-linked inhibitor of apoptosis | Homo sapiens |
| 6 | CONCLUSIONS: As2O3 injection combined with DDP can significantly increase the chemosensitivity on human non-small cell lung cancer, and the mechanism may be related to its inhibition on the expression of XIAP. | Arsenic Trioxide | X-linked inhibitor of apoptosis | Homo sapiens |