Title : Recognition of sulfonylurea receptor (ABCC8/9) ligands by the multidrug resistance transporter P-glycoprotein (ABCB1): functional similarities based on common structural features between two multispecific ABC proteins.

Pub. Date : 2011 Feb 4

PMID : 21098040






1 Functional Relationships(s)
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1 Considering the various residues experimentally assigned to be involved in drug binding, we uncovered several hot spots, which organized spatially in two main binding domains, selective for SR47063 and for glibenclamide, in matching regions of both P-gp and SUR. Glyburide ATP-binding cassette, sub-family C (CFTR/MRP), member 8 Mus musculus