Protein Name ATP-binding cassette, sub-family C member 8
Organism Mus musculus
Gene ID 20927
Gene Symbol

Abcc8

UniProt B2RUS7 (B2RUS7_MOUSE)
Relationships Total Number of functionally related compound(s) : 78
Total Number of Articles : 102
Description

ATP-binding cassette, sub-family C member 8

Gene Summary

Predicted to enable ATPase-coupled cation transmembrane transporter activity; potassium channel activity; and transmembrane transporter binding activity. Predicted to be involved in several processes, including learning or memory; negative regulation of blood-brain barrier permeability; and negative regulation of low-density lipoprotein particle clearance. Located in plasma membrane. Is expressed in cerebral cortex; foregut-midgut junction; heart ventricle; and retina inner nuclear layer. Used to study hyperinsulinemic hypoglycemia and transient neonatal diabetes mellitus. Human ortholog(s) of this gene implicated in familial hyperinsulinemic hypoglycemia 1; glucose metabolism disease (multiple); hypertension; and leucine-sensitive hypoglycemia of infancy. Orthologous to human ABCC8 (ATP binding cassette subfamily C member 8). [provided by Alliance of Genome Resources, Apr 2022]

synonyms
  • ATP-binding cassette sub-family C member 8
  • ATP-binding cassette, sub-family C (CFTR/MRP), member 8
  • sulfonylurea receptor
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Properties