Title : Studies on the effects of heparin products on pregnancy-associated plasma protein A.

Pub. Date : 2011 Jan 30

PMID : 21094153






15 Functional Relationships(s)
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1 Studies on the effects of heparin products on pregnancy-associated plasma protein A. Heparin pappalysin 1 Homo sapiens
2 BACKGROUND: Intravenous low molecular weight (LMWH) and unfractionated heparin (UFH) increase the circulating concentrations of pregnancy-associated plasma protein A (PAPP-A), a novel cardiac risk marker, in haemodialysis and coronary angiography patients. Heparin pappalysin 1 Homo sapiens
3 BACKGROUND: Intravenous low molecular weight (LMWH) and unfractionated heparin (UFH) increase the circulating concentrations of pregnancy-associated plasma protein A (PAPP-A), a novel cardiac risk marker, in haemodialysis and coronary angiography patients. Heparin pappalysin 1 Homo sapiens
4 BACKGROUND: Intravenous low molecular weight (LMWH) and unfractionated heparin (UFH) increase the circulating concentrations of pregnancy-associated plasma protein A (PAPP-A), a novel cardiac risk marker, in haemodialysis and coronary angiography patients. Heparin pappalysin 1 Homo sapiens
5 BACKGROUND: Intravenous low molecular weight (LMWH) and unfractionated heparin (UFH) increase the circulating concentrations of pregnancy-associated plasma protein A (PAPP-A), a novel cardiac risk marker, in haemodialysis and coronary angiography patients. Heparin pappalysin 1 Homo sapiens
6 BACKGROUND: Intravenous low molecular weight (LMWH) and unfractionated heparin (UFH) increase the circulating concentrations of pregnancy-associated plasma protein A (PAPP-A), a novel cardiac risk marker, in haemodialysis and coronary angiography patients. Heparin pappalysin 1 Homo sapiens
7 BACKGROUND: Intravenous low molecular weight (LMWH) and unfractionated heparin (UFH) increase the circulating concentrations of pregnancy-associated plasma protein A (PAPP-A), a novel cardiac risk marker, in haemodialysis and coronary angiography patients. Heparin pappalysin 1 Homo sapiens
8 The interaction between heparin products and free PAPP-A was studied with gel filtration. Heparin pappalysin 1 Homo sapiens
9 RESULTS: After intravenous UFH and LMWH free PAPP-A increased significantly but bivalirudin had no effect. Heparin pappalysin 1 Homo sapiens
10 After LMWH bolus in haemodialysis patients 85% of free PAPP-A was cleared with a half-life of 13.1 min and the rest with a half-life of 96.6 min. Heparin pappalysin 1 Homo sapiens
11 Subcutaneous LMWH led to lower and slower free PAPP-A elevation. Heparin pappalysin 1 Homo sapiens
12 PAPP-A extracted from plaque tissues was in free form and extraction was strongly enhanced by LMWH. Heparin pappalysin 1 Homo sapiens
13 Heparin products increased the molecular size of free PAPP-A. Heparin pappalysin 1 Homo sapiens
14 CONCLUSIONS: The heparin-induced PAPP-A elevation is seen in various patients and should be taken into account when PAPP-A is studied as a biomarker. Heparin pappalysin 1 Homo sapiens
15 CONCLUSIONS: The heparin-induced PAPP-A elevation is seen in various patients and should be taken into account when PAPP-A is studied as a biomarker. Heparin pappalysin 1 Homo sapiens