CPRiL

PAPPA

pappalysin 1

This gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). Following IGFBP cleavage, insulin growth factors dissociate from IGFBPs and bind to IGF receptors, resulting in activation of the IGF pathway. The encoded protein plays a role in bone formation, inflammation, wound healing and female fertility. Enhanced expression of this protein is associated with diabetic nephropathy in human patients and this protein may promote tumor invasion and growth in various human cancers. [provided by RefSeq, Aug 2017]

• pappalysin-1
• IGF-dependent IGFBP-4 protease
• aspecific BCL2 ARE-binding protein 2
differentially placenta 1 expressed protein
insulin-like growth factor-dependent IGF binding protein-4 protease
pregnancy-associated plasma protein A, pappalysin 1
ASBABP2
DIPLA1
IGFBP-4ase
PAPA
PAPP-A
PAPPA1