Title : Chiral Brønsted base-promoted nitroalkane alkylation: enantioselective synthesis of sec-alkyl-3-substituted indoles.

Pub. Date : 2010 Dec 17

PMID : 21090654






1 Functional Relationships(s)
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1 An indolenine intermediate is implicated in the addition step, and surprisingly, water cosolvent was found to have a beneficial effect in this step, leading to a one-pot protocol for elimination/enantioselective addition using PBAM, a bis(amidine) chiral nonracemic base. Water solute carrier family 10 member 2 Homo sapiens