Title : Etanercept restores the antinociceptive effect of morphine and suppresses spinal neuroinflammation in morphine-tolerant rats.

Pub. Date : 2011 Feb

PMID : 21081778






2 Functional Relationships(s)
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1 BACKGROUND: In the present study we examined the effect of the tumor necrosis factor (TNF)-alpha antagonist etanercept on the antinociceptive effect of morphine in morphine-tolerant rats. Morphine tumor necrosis factor Rattus norvegicus
2 In addition, the expression of TNFalpha mRNA was increased by 2.5-fold, interleukin (IL)-1beta mRNA increased by 13-fold and IL-6 mRNA by 111-fold in the dorsal spinal cord of morphine-tolerant rats. Morphine tumor necrosis factor Rattus norvegicus