Title : A structural insight into the reorientation of transmembrane domains 3 and 5 during family A G protein-coupled receptor activation.

Pub. Date : 2011 Feb

PMID : 21081645






1 Functional Relationships(s)
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1 We propose that the structural change of TM5 during the process of GPCR activation involves a local Pro(5.50)-induced unwinding of the helix, acting as a hinge, and the highly conserved hydrophobic Ile(3.40) side chain, acting as a pivot. Isoleucine tropomyosin 3 Homo sapiens