PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21081645-4 2011 We propose that the structural change of TM5 during the process of GPCR activation involves a local Pro(5.50)-induced unwinding of the helix, acting as a hinge, and the highly conserved hydrophobic Ile(3.40) side chain, acting as a pivot. Isoleucine 198-201 tropomyosin 3 Homo sapiens 41-44