Title : {Beta}-blocker drugs mediate calcium signaling in native central nervous system neurons by {beta}-arrestin-biased agonism.

Pub. Date : 2010 Dec 7

PMID : 21078978






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1 Here we show that propranolol and carvedilol, two beta-blocker drugs that inhibit beta-adrenergic signaling via heterotrimeric G proteins, function in hippocampal pyramidal neurons as potent and selective activators of an alternate receptor-linked calcium signaling pathway mediated by beta-arrestin-2 and ERK1/2. Propranolol arrestin beta 2 Homo sapiens