Title : The role of TNFα in the periaqueductal gray during naloxone-precipitated morphine withdrawal in rats.

Pub. Date : 2011 Feb

PMID : 21068718






4 Functional Relationships(s)
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1 The role of TNFalpha in the periaqueductal gray during naloxone-precipitated morphine withdrawal in rats. Morphine tumor necrosis factor Rattus norvegicus
2 Here we report that chronic morphine withdrawal-induced upregulation of glial fibrillary acidic protein (GFAP), tumor necrosis factor alpha (TNFalpha) and phosphorylation of ERK1/2 (pERK1/2) in the caudal ventrolateral PAG (vlPAG). Morphine tumor necrosis factor Rattus norvegicus
3 Here we report that chronic morphine withdrawal-induced upregulation of glial fibrillary acidic protein (GFAP), tumor necrosis factor alpha (TNFalpha) and phosphorylation of ERK1/2 (pERK1/2) in the caudal ventrolateral PAG (vlPAG). Morphine tumor necrosis factor Rattus norvegicus
4 Microinjection of recombinant TNFalpha into the vlPAG followed by intraperitoneal naloxone resulted in morphine withdrawal-like behavioral signs, and upregulation of pERK1/2, expression of Fos, and phosphorylation of cAMP response element binding (pCREB) protein. Morphine tumor necrosis factor Rattus norvegicus