Title : Multisite phosphorylation of the epidermal growth factor receptor. Use of site-directed mutagenesis to examine the role of serine/threonine phosphorylation.

Pub. Date : 1990 Feb 25

PMID : 2105948






2 Functional Relationships(s)
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1 The major sites of serine and threonine phosphorylation of the human epidermal growth factor (EGF) receptor observed in intact cells are Thr654, Thr669, Ser1046, and Ser1047. Serine epidermal growth factor receptor Homo sapiens
2 In order to test the hypothesis that the phosphorylation of the EGF receptor is mechanistically related to the modulation of EGF receptor function, we replaced the major sites of serine and threonine phosphorylation with alanine residues. Serine epidermal growth factor receptor Homo sapiens