Title : Evaluation of radioiodinated quinazoline derivative as a new ligand for EGF receptor tyrosine kinase activity using SPECT.

Pub. Date : 2011 Feb

PMID : 21058048






2 Functional Relationships(s)
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1 OBJECTIVE: A radioiodinated analog of PD153035 (m-IPQ) was evaluated as a potential epidermal growth factor receptor tyrosine kinase (EGFR-TK) activity imaging ligand for SPECT. 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline epidermal growth factor receptor Mus musculus
2 The selectivity toward EGFR-TK of m-IPQ was confirmed by the pretreatment experiment with EGFR-TK specific inhibitors, PD153035, Genistein. 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline epidermal growth factor receptor Mus musculus