Title : Differential suppression of proliferation in MCF-7 and MDA-MB-231 breast cancer cells exposed to alpha-, gamma- and delta-tocotrienols is accompanied by altered expression of oxidative stress modulatory enzymes.

Pub. Date : 2010 Oct

PMID : 21036737






2 Functional Relationships(s)
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1 In MDA-MB-231 cells, treatment by tocotrienols led to several fold increase of NRF2 expression marked by corresponding decrease in KEAP1 levels. Tocotrienols NFE2 like bZIP transcription factor 2 Homo sapiens
2 These studies demonstrate that different tocotrienols show distinct and selective activity in regulating the NRF2-KEAP1, in coordination with the induced expression of cytoprotective oxidative stress modulatory genes and regulation of proliferation in breast cancer cells. Tocotrienols NFE2 like bZIP transcription factor 2 Homo sapiens