Title : Guanine nucleotide pool imbalance impairs multiple steps of protein synthesis and disrupts GCN4 translational control in Saccharomyces cerevisiae.

Pub. Date : 2011 Jan

PMID : 20980241






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 We have identified a substitution mutation (G388D) that reduces the activity of the GMP synthase Gua1 in budding yeast and the total G-nucleotide pool, leading to precipitous reductions in the GDP/GTP ratio and ATP level in vivo. Guanosine Diphosphate GMP synthase (glutamine-hydrolyzing) Saccharomyces cerevisiae S288C