PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20980241-3 2011 We have identified a substitution mutation (G388D) that reduces the activity of the GMP synthase Gua1 in budding yeast and the total G-nucleotide pool, leading to precipitous reductions in the GDP/GTP ratio and ATP level in vivo. Guanosine Diphosphate 193-196 GMP synthase (glutamine-hydrolyzing) Saccharomyces cerevisiae S288C 97-101