Title : Comparative study of antioxidants as cancer preventives through inhibition of HIF-1 alpha activity.

Pub. Date : 2009 Dec 6

PMID : 20975915






1 Functional Relationships(s)
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1 In the present study, five antioxidants, namely lycopene, ascorbic acid, alpha-tocopherol, curcumin and curcumin dipiperoyl ester which are potent scavengers of reactive oxygen species (ROS) have been docked to HIF-1 alpha modeled protein in order to assess their binding and consequently, their inhibitory activity. Lycopene hypoxia inducible factor 1 subunit alpha Homo sapiens