Title : Role of mouse cerebellar nicotinic acetylcholine receptor (nAChR) α(4)β(2)- and α(7) subtypes in the behavioral cross-tolerance between nicotine and ethanol-induced ataxia.

Pub. Date : 2011 Mar 1

PMID : 20974182






4 Functional Relationships(s)
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1 Role of mouse cerebellar nicotinic acetylcholine receptor (nAChR) alpha(4)beta(2)- and alpha(7) subtypes in the behavioral cross-tolerance between nicotine and ethanol-induced ataxia. Ethanol cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus
2 Role of mouse cerebellar nicotinic acetylcholine receptor (nAChR) alpha(4)beta(2)- and alpha(7) subtypes in the behavioral cross-tolerance between nicotine and ethanol-induced ataxia. Ethanol cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus
3 We have demonstrated that nicotine attenuated ethanol-induced ataxia via nicotinic-acetylcholine-receptor (nAChR) subtypes alpha(4)beta(2) and alpha(7). Ethanol cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus
4 Our results support a role for alpha(4)beta(2) and alpha(7) nAChR subtypes in the development of cross-tolerance between nicotine and ethanol with the NO signaling pathway as a potential mechanism. Ethanol cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus