Title : Neferine inhibits cultured hepatic stellate cell activation and facilitates apoptosis: A possible molecular mechanism.

Pub. Date : 2011 Jan 10

PMID : 20969858






2 Functional Relationships(s)
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1 However, it is unknown whether neferine also has an inhibitory effect on liver fibrosis through inhibition of TGF-beta1 and collagen I and facilitation of apoptosis of hepatic stellate cells. neferine transforming growth factor, beta 1 Rattus norvegicus
2 The results showed that neferine administration (2, 4, 6, 8 and 10mumol/l) significantly decreased the TGF-beta1 and collagen I produced in HSC-T6 cells, and increased the HSC-T6 cell apoptosis in a dose-dependent manner. neferine transforming growth factor, beta 1 Rattus norvegicus