Title : Rapid microelectrode measurements and the origin and regulation of extracellular glutamate in rat prefrontal cortex.

Pub. Date : 2010 Dec

PMID : 20969570






2 Functional Relationships(s)
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1 In addition significant reductions in extracellular glutamate were seen with locally applied omega-conotoxin (MVIIC; ~ 50%; calcium channel blocker), and the mGluR(2/3) agonist, LY379268 (~ 20%), and a significant increase with the mGluR(2/3) antagonist LY341495 (~ 40%), effects all consistent with a large neuronal contribution to the resting glutamate levels. LY 379268 glutamate receptor, metabotropic 2 Mus musculus
2 In addition significant reductions in extracellular glutamate were seen with locally applied omega-conotoxin (MVIIC; ~ 50%; calcium channel blocker), and the mGluR(2/3) agonist, LY379268 (~ 20%), and a significant increase with the mGluR(2/3) antagonist LY341495 (~ 40%), effects all consistent with a large neuronal contribution to the resting glutamate levels. LY 379268 glutamate receptor, metabotropic 2 Mus musculus