Title : Residues at the tip of the pore loop of NR3B-containing NMDA receptors determine Ca2+ permeability and Mg2+ block.

Pub. Date : 2010 Oct 19

PMID : 20958962






3 Functional Relationships(s)
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1 Ca2+ permeability could be rescued by mutating the NR3 N site glycine to the NR1-like asparagine. Glycine glutamate ionotropic receptor NMDA type subunit 1 Homo sapiens
2 Conversely, "conventional" receptors assembled from NR1 and NR2 could be made Mg2+ insensitive and Ca2+ impermeable by equipping either subunit with the NR3-like glycine at their N positions, with a stronger contribution of the NR1 subunit. Glycine glutamate ionotropic receptor NMDA type subunit 1 Homo sapiens
3 Conversely, "conventional" receptors assembled from NR1 and NR2 could be made Mg2+ insensitive and Ca2+ impermeable by equipping either subunit with the NR3-like glycine at their N positions, with a stronger contribution of the NR1 subunit. Glycine glutamate ionotropic receptor NMDA type subunit 1 Homo sapiens