Pub. Date : 2011 Jan
PMID : 20952483
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The role of the breast cancer resistance protein (ABCG2) in the distribution of sorafenib to the brain. | Sorafenib | ATP binding cassette subfamily G member 2 (Junior blood group) | Mus musculus |
| 2 | The role of the breast cancer resistance protein (ABCG2) in the distribution of sorafenib to the brain. | Sorafenib | ATP binding cassette subfamily G member 2 (Junior blood group) | Mus musculus |
| 3 | This study investigated the influence of P-gp and BCRP on the central nervous system (CNS) penetration of sorafenib, a multitargeted tyrosine kinase inhibitor currently being evaluated in clinical trials for glioma. | Sorafenib | ATP binding cassette subfamily G member 2 (Junior blood group) | Mus musculus |
| 4 | In vitro studies showed that BCRP has a high affinity for sorafenib. | Sorafenib | ATP binding cassette subfamily G member 2 (Junior blood group) | Mus musculus |
| 5 | Steady-state brain-to-plasma concentration ratio of sorafenib was approximately 0.36 +- 0.056 in the Bcrp1(-/-) mice, 0.11 +- 0.021 in the Mdr1a/b(-/-) mice, and 0.91 +- 0.29 in the Mdr1a/b(-/-)Bcrp1(-/-) mice compared with 0.094 +- 0.007 in the wild-type mice. | Sorafenib | ATP binding cassette subfamily G member 2 (Junior blood group) | Mus musculus |
| 6 | This study shows that BCRP and P-gp together restrict the brain distribution of sorafenib with BCRP playing a dominant role in the efflux of sorafenib at the BBB. | Sorafenib | ATP binding cassette subfamily G member 2 (Junior blood group) | Mus musculus |
| 7 | This study shows that BCRP and P-gp together restrict the brain distribution of sorafenib with BCRP playing a dominant role in the efflux of sorafenib at the BBB. | Sorafenib | ATP binding cassette subfamily G member 2 (Junior blood group) | Mus musculus |
| 8 | This study shows that BCRP and P-gp together restrict the brain distribution of sorafenib with BCRP playing a dominant role in the efflux of sorafenib at the BBB. | Sorafenib | ATP binding cassette subfamily G member 2 (Junior blood group) | Mus musculus |