Pub. Date : 2011 Feb
PMID : 20927043
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Angiotensin II inhibited ROMK1 channels in a dose-dependent manner, an effect abolished by losartan or by inhibition of protein kinase C. Furthermore, angiotensin II stimulated a protein kinase C-sensitive phosphorylation of tyrosine 416 within c-Src. | Tyrosine | angiotensinogen | Homo sapiens |
| 2 | Angiotensin II inhibited ROMK1 channels in a dose-dependent manner, an effect abolished by losartan or by inhibition of protein kinase C. Furthermore, angiotensin II stimulated a protein kinase C-sensitive phosphorylation of tyrosine 416 within c-Src. | Tyrosine | angiotensinogen | Homo sapiens |
| 3 | Western blot studies suggested that angiotensin II inhibited ROMK1 channels by enhancing its tyrosine phosphorylation, a notion supported by angiotensin II"s failure to inhibit potassium channels in cells transfected with the ROMK1 tyrosine mutant (R1Y337A). | Tyrosine | angiotensinogen | Homo sapiens |
| 4 | Western blot studies suggested that angiotensin II inhibited ROMK1 channels by enhancing its tyrosine phosphorylation, a notion supported by angiotensin II"s failure to inhibit potassium channels in cells transfected with the ROMK1 tyrosine mutant (R1Y337A). | Tyrosine | angiotensinogen | Homo sapiens |
| 5 | Thus, angiotensin II inhibits ROMK channels by two mechanisms: increasing tyrosine phosphorylation of the channel and synergizing the WNK4-induced inhibition. | Tyrosine | angiotensinogen | Homo sapiens |