Title : Naturally occurring germline and tumor-associated mutations within the ATP-binding motifs of PTEN lead to oxidative damage of DNA associated with decreased nuclear p53.

Pub. Date : 2011 Jan 1

PMID : 20926450






1 Functional Relationships(s)
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1 On the other, the mislocalized mutant PTEN results in a significantly decreased nuclear p53 protein level and transcriptional activity, enhanced production of reactive oxygen species, induction of Cu/Zn superoxide dismutase as well as dramatically increased DNA double-strand breaks (DSBs). Reactive Oxygen Species phosphatase and tensin homolog Homo sapiens