Pub. Date : 1990
PMID : 2089098
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Three such "metabolizing systems" are involved in the inactivation of noradrenaline: 1) Neuronal uptake (high-affinity uptake1) in association with neuronal MAO (and vesicular uptake), 2) extraneuronal uptake (low affinity uptake2) in association with intracellular COMT and MAO (in smooth muscles, myocardial cells, glands), and 3) uptake1 of non-neuronal cells in association with intracellular COMT and/or MAO (in vascular endothelium of rat lung). | Norepinephrine | catechol-O-methyltransferase | Homo sapiens |
| 2 | Three such "metabolizing systems" are involved in the inactivation of noradrenaline: 1) Neuronal uptake (high-affinity uptake1) in association with neuronal MAO (and vesicular uptake), 2) extraneuronal uptake (low affinity uptake2) in association with intracellular COMT and MAO (in smooth muscles, myocardial cells, glands), and 3) uptake1 of non-neuronal cells in association with intracellular COMT and/or MAO (in vascular endothelium of rat lung). | Norepinephrine | catechol-O-methyltransferase | Homo sapiens |
| 3 | Hence, membrane-bound COMT appears to be responsible for the extraneuronal O-methylation of noradrenaline. | Norepinephrine | catechol-O-methyltransferase | Homo sapiens |