Pub. Date : 2010 Sep 27
PMID : 20885957
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We also found that levels of endogenous p-Thr32-FOXO3a and p-Ser253-FOXO3a were lower in AZD6244-sensitive cells than in AZD6244-resistant cells. | AZD 6244 | forkhead box O3 | Homo sapiens |
| 2 | We also found that levels of endogenous p-Thr32-FOXO3a and p-Ser253-FOXO3a were lower in AZD6244-sensitive cells than in AZD6244-resistant cells. | AZD 6244 | forkhead box O3 | Homo sapiens |
| 3 | We also found that levels of endogenous p-Thr32-FOXO3a and p-Ser253-FOXO3a were lower in AZD6244-sensitive cells than in AZD6244-resistant cells. | AZD 6244 | forkhead box O3 | Homo sapiens |
| 4 | We also found that levels of endogenous p-Thr32-FOXO3a and p-Ser253-FOXO3a were lower in AZD6244-sensitive cells than in AZD6244-resistant cells. | AZD 6244 | forkhead box O3 | Homo sapiens |
| 5 | In the sensitive cells, AZD6244 induced FOXO3a nuclear translocation required for Bim activation. | AZD 6244 | forkhead box O3 | Homo sapiens |
| 6 | Moreover, the silencing of FOXO3a by siRNA abrogated AZD6244-induced cell apoptosis. | AZD 6244 | forkhead box O3 | Homo sapiens |
| 7 | These results show that Bim plays an important role in AZD6244-induced apoptosis in lung cancer cells and that the PI3K/AKT/FOXO3a pathway is involved in Bim regulation and susceptibility of lung cancer cells to AZD6244. | AZD 6244 | forkhead box O3 | Homo sapiens |
| 8 | These results show that Bim plays an important role in AZD6244-induced apoptosis in lung cancer cells and that the PI3K/AKT/FOXO3a pathway is involved in Bim regulation and susceptibility of lung cancer cells to AZD6244. | AZD 6244 | forkhead box O3 | Homo sapiens |