Title : Sorafenib overcomes TRAIL resistance of hepatocellular carcinoma cells through the inhibition of STAT3.

Pub. Date : 2010 Nov 1

PMID : 20884624






1 Functional Relationships(s)
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1 Our data showed that sorafenib downregulated phospho-STAT3 (pSTAT3) and subsequently reduced the expression levels of STAT3-related proteins (Mcl-1, survivin, and cyclin D1) in a dose- and time-dependent manner in TRAIL-treated HCC cells. Sorafenib cyclin D1 Mus musculus