Title : Neurotrophic activity of obovatol on the cultured embryonic rat neuronal cells by increase of neurotrophin release through activation of ERK pathway.

Pub. Date : 2010 Dec 15

PMID : 20868677






3 Functional Relationships(s)
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1 We also found that obovatol increased levels of NGF and BDNF released into the culture medium. obovatol nerve growth factor Rattus norvegicus
2 In addition, the combination of low concentrations of obovatol (1 and 2 muM) with NGF (50 ng/ml) or with BDNF (10 ng/ml) greatly enhanced neurite outgrowth. obovatol nerve growth factor Rattus norvegicus
3 However, the neurite outgrowth, and NGF and BDNF release induced by obovatol were prevented by an ERK-specific inhibitor. obovatol nerve growth factor Rattus norvegicus