Pub. Date : 2010 Dec 3
PMID : 20861011
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Combined with biochemical analysis, these data lead to a model of Arf1 activation, in which opening of its N-terminal helix first translocates Arf1-GDP to membranes, where it is then secured by a register shift of the interswitch beta-strands, before GDP is eventually exchanged for GTP. | Guanosine Diphosphate | ADP ribosylation factor 1 | Homo sapiens |
| 2 | Combined with biochemical analysis, these data lead to a model of Arf1 activation, in which opening of its N-terminal helix first translocates Arf1-GDP to membranes, where it is then secured by a register shift of the interswitch beta-strands, before GDP is eventually exchanged for GTP. | Guanosine Diphosphate | ADP ribosylation factor 1 | Homo sapiens |
| 3 | Combined with biochemical analysis, these data lead to a model of Arf1 activation, in which opening of its N-terminal helix first translocates Arf1-GDP to membranes, where it is then secured by a register shift of the interswitch beta-strands, before GDP is eventually exchanged for GTP. | Guanosine Diphosphate | ADP ribosylation factor 1 | Homo sapiens |
| 4 | We first completed the assignment of Delta17Arf1 bound to GDP, GTP, and GTPgammaS and established that NMR data are fully consistent with the crystal structures of Arf1-GDP and Delta17Arf1-GTP. | Guanosine Diphosphate | ADP ribosylation factor 1 | Homo sapiens |
| 5 | We first completed the assignment of Delta17Arf1 bound to GDP, GTP, and GTPgammaS and established that NMR data are fully consistent with the crystal structures of Arf1-GDP and Delta17Arf1-GTP. | Guanosine Diphosphate | ADP ribosylation factor 1 | Homo sapiens |
| 6 | We first completed the assignment of Delta17Arf1 bound to GDP, GTP, and GTPgammaS and established that NMR data are fully consistent with the crystal structures of Arf1-GDP and Delta17Arf1-GTP. | Guanosine Diphosphate | ADP ribosylation factor 1 | Homo sapiens |
| 7 | Altogether, the NMR data bring insight into how that membrane-bound Arf1-GDP, which is mimicked by the truncation of the N-terminal helix, acquires internal motions that enable the toggle of the interswitch. | Guanosine Diphosphate | ADP ribosylation factor 1 | Homo sapiens |