| Protein Name | ARF GTPase 1 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 375 |
| Gene Symbol | ARF1 |
| UniProt | P84077 (ARF1_HUMAN), A0A024R3Q0 (A0A024R3Q0_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
141
Total Number of Articles : 295 |
Description |
ARF GTPase 1 |
| Gene Summary |
ADP-ribosylation factor 1 (ARF1) is a member of the human ARF gene family. The family members encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking as activators of phospholipase D. The gene products, including 6 ARF proteins and 11 ARF-like proteins, constitute a family of the RAS superfamily. The ARF proteins are categorized as class I (ARF1, ARF2 and ARF3), class II (ARF4 and ARF5) and class III (ARF6), and members of each class share a common gene organization. The ARF1 protein is localized to the Golgi apparatus and has a central role in intra-Golgi transport. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] |
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