Title : C-Phycocyanin inhibits MDR1 through reactive oxygen species and cyclooxygenase-2 mediated pathways in human hepatocellular carcinoma cell line.

Pub. Date : 2010 Dec 15

PMID : 20858479






2 Functional Relationships(s)
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Protein Name
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1 The induction of MDR1 expression by PGE2 and its down regulation by C-PC and DPI (Diphenylene iodonium, NADPH oxidase inhibitor) or by COX-2 knockdown suggest that the enhanced sensitivity of HepG2 cells to doxorubicin by C-PC is mediated by the down regulation of MDR1 expression. diphenyleneiodonium ATP binding cassette subfamily B member 1 Homo sapiens
2 The induction of MDR1 expression by PGE2 and its down regulation by C-PC and DPI (Diphenylene iodonium, NADPH oxidase inhibitor) or by COX-2 knockdown suggest that the enhanced sensitivity of HepG2 cells to doxorubicin by C-PC is mediated by the down regulation of MDR1 expression. diphenyleneiodonium ATP binding cassette subfamily B member 1 Homo sapiens