Title : PI3K inhibitors prime neuroblastoma cells for chemotherapy by shifting the balance towards pro-apoptotic Bcl-2 proteins and enhanced mitochondrial apoptosis.

Pub. Date : 2011 Jan 27

PMID : 20856197






2 Functional Relationships(s)
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1 Mechanistic studies reveal that PI103 cooperates with Doxorubicin to reduce Mcl-1 expression and Bim(EL) phosphorylation and to upregulate Noxa and Bim(EL) levels. Doxorubicin MCL1 apoptosis regulator, BCL2 family member Homo sapiens
2 Although Mcl-1 knockdown enhances Doxorubicin- and PI103-induced apoptosis, silencing of Noxa, Bax/Bak or p53 reduces apoptosis, underscoring the functional relevance of the Doxorubicin- and PI103-mediated modulation of these proteins for chemosensitization. Doxorubicin MCL1 apoptosis regulator, BCL2 family member Homo sapiens