Title : TNF-α potentiates glutamate-induced spinal cord motoneuron death via NF-κB.

Pub. Date : 2011 Jan

PMID : 20849956






3 Functional Relationships(s)
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1 Co-exposure to TNF-alpha and THA also resulted in down-regulation of the astroglial glutamate transporter 1 (GLT-1) and in increased extracellular glutamate levels, which were prevented by nuclear factor-kappaB (NF-kappaB) inhibition. tha nuclear factor kappa B subunit 1 Homo sapiens
2 Co-exposure to TNF-alpha and THA also resulted in down-regulation of the astroglial glutamate transporter 1 (GLT-1) and in increased extracellular glutamate levels, which were prevented by nuclear factor-kappaB (NF-kappaB) inhibition. tha nuclear factor kappa B subunit 1 Homo sapiens
3 Furthermore, TNF-alpha and THA also cooperated in the induction of oxidative stress in a mechanism involving the NF-kappaB signalling pathway as well. tha nuclear factor kappa B subunit 1 Homo sapiens