Title : Study of atypical kinetic behaviour of cytochrome P450 2C9 isoform with diclofenac at low substrate concentrations by sweeping-MEKC combination.

Pub. Date : 2010 Oct

PMID : 20848598






2 Functional Relationships(s)
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1 Study of atypical kinetic behaviour of cytochrome P450 2C9 isoform with diclofenac at low substrate concentrations by sweeping-MEKC combination. Diclofenac cytochrome P450 family 2 subfamily C member 9 Homo sapiens
2 In view of the fact that several studies have shown that diclofenac hydroxylation by cytochrome P450 2C9 deviated from Michaelis-Menten kinetics at low substrate concentrations, sweeping combined with MEKC was applied for the kinetic study of this pharmacologically important reaction. Diclofenac cytochrome P450 family 2 subfamily C member 9 Homo sapiens