Title : Stimulation of α7 nicotinic acetylcholine receptor by nicotine increases suppressive capacity of naturally occurring CD4+CD25+ regulatory T cells in mice in vitro.

Pub. Date : 2010 Dec

PMID : 20843956






1 Functional Relationships(s)
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1 In the supernatants of CD4(+)CD25(+) Tregs/CD4(+)CD25(-) T-cell cocultures, we observed a decrease in the concentration of IL-2 in nicotine-stimulated groups, but nicotine stimulation had no effect on the ratio of IL-4/interferon (IFN)-gamma, which partially represented T-cell polarization. Nicotine interleukin 2 Mus musculus