Pub. Date : 2010 Dec
PMID : 20843956
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Stimulation of alpha7 nicotinic acetylcholine receptor by nicotine increases suppressive capacity of naturally occurring CD4+CD25+ regulatory T cells in mice in vitro. | Nicotine | cholinergic receptor, nicotinic, alpha polypeptide 7 | Mus musculus |
| 2 | We found that CD4(+)CD25(+) Tregs from naive C57BL/6J mice positively expressed alpha7 nAChR, and its activation by nicotine enhanced the suppressive capacity of Tregs. | Nicotine | cholinergic receptor, nicotinic, alpha polypeptide 7 | Mus musculus |
| 3 | The above-mentioned effects of nicotine were reversed by a selective alpha7 nAChR antagonist, alpha-bungarotoxin. | Nicotine | cholinergic receptor, nicotinic, alpha polypeptide 7 | Mus musculus |
| 4 | We conclude that nicotine might increase Treg-mediated immune suppression of lymphocytes via alpha7 nAChR. | Nicotine | cholinergic receptor, nicotinic, alpha polypeptide 7 | Mus musculus |