Title : Thiazolidinediones up-regulate insulin-like growth factor-1 receptor via a peroxisome proliferator-activated receptor gamma-independent pathway.

Pub. Date : 2010 Nov 19

PMID : 20843793






3 Functional Relationships(s)
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1 However, the endogenous PPARgamma ligand, 15-deoxy-Delta(12,14)-prostaglandin J(2), dose dependently reduced IGF-1R (10 mumol/liter, 80% decrease, n = 4, p < 0.01), and overexpression of PPARgamma using an adenovirus likewise reduced IGF-1R (50% decrease versus SMC infected with control adenovirus), suggesting a PPARgamma-independent action of TZDs. 15-deoxy-delta peroxisome proliferator activated receptor gamma Homo sapiens
2 However, the endogenous PPARgamma ligand, 15-deoxy-Delta(12,14)-prostaglandin J(2), dose dependently reduced IGF-1R (10 mumol/liter, 80% decrease, n = 4, p < 0.01), and overexpression of PPARgamma using an adenovirus likewise reduced IGF-1R (50% decrease versus SMC infected with control adenovirus), suggesting a PPARgamma-independent action of TZDs. 15-deoxy-delta peroxisome proliferator activated receptor gamma Homo sapiens
3 However, the endogenous PPARgamma ligand, 15-deoxy-Delta(12,14)-prostaglandin J(2), dose dependently reduced IGF-1R (10 mumol/liter, 80% decrease, n = 4, p < 0.01), and overexpression of PPARgamma using an adenovirus likewise reduced IGF-1R (50% decrease versus SMC infected with control adenovirus), suggesting a PPARgamma-independent action of TZDs. 15-deoxy-delta peroxisome proliferator activated receptor gamma Homo sapiens