Pub. Date : 2011 Jan 1
PMID : 20833148
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | These studies confirm that hiCE demonstrates the most efficient kinetic parameters for CPT-11 activation, however, due to the high levels of hCE1 that are expressed in liver, the latter enzyme can contribute up to 50% of the total of drug hydrolysis in this tissue. | Irinotecan | carboxylesterase 1 | Homo sapiens |
2 | Conversely, in human duodenum, jejunum, ileum and kidney, where hCE1 expression is very low, greater than 99% of the conversion of CPT-11 to SN-38 was mediated by hiCE. | Irinotecan | carboxylesterase 1 | Homo sapiens |
3 | Overall, our studies demonstrate that hCE1 plays a significant role in CPT-11 hydrolysis even though it is up to 100-fold less efficient at drug activation than hiCE, and that drug activation in the intestine and kidney are likely major contributors to SN-38 production in vivo. | Irinotecan | carboxylesterase 1 | Homo sapiens |
4 | Overall, our studies demonstrate that hCE1 plays a significant role in CPT-11 hydrolysis even though it is up to 100-fold less efficient at drug activation than hiCE, and that drug activation in the intestine and kidney are likely major contributors to SN-38 production in vivo. | Irinotecan | carboxylesterase 1 | Homo sapiens |