Pub. Date : 2011 Dec 15
PMID : 20832877
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Atorvastatin prevents mesenchymal stem cells from hypoxia and serum-free injury through activating AMP-activated protein kinase. | Atorvastatin | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |
| 2 | Therefore, we hypothesized that atorvastatin could protect MSCs from H/SF injury through AMPK-eNOS pathway. | Atorvastatin | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |
| 3 | METHODS AND RESULTS: Stained with Annexin V/propidine iodine (PI), we found atorvastatin (0.001 muM-10 muM) reduced apoptosis of porcine bone marrow-derived MSCs cultured in H/SF condition; however, this effect was obstructed by compound C, an inhibitor of AMPK. | Atorvastatin | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |
| 4 | Meanwhile, MSCs treated with atorvastatin increased phosphorylation of AMPK and eNOS. | Atorvastatin | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |
| 5 | The uptrend was partially inhibited by compound C. CONCLUSIONS: Atorvastatin can activate AMPK and the phosphorylation of AMPK results in eNOS activated, which provides a novel explanation for the multi-effect of statins on cardiovascular system. | Atorvastatin | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |
| 6 | The uptrend was partially inhibited by compound C. CONCLUSIONS: Atorvastatin can activate AMPK and the phosphorylation of AMPK results in eNOS activated, which provides a novel explanation for the multi-effect of statins on cardiovascular system. | Atorvastatin | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |