Pub. Date : 2010 Nov 1
PMID : 20829041
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Isoflavone derivatives inhibit NF-kappaB-dependent transcriptional activity. | Isoflavones | nuclear factor kappa B subunit 1 | Homo sapiens |
| 2 | Isoflavones are known to have anti-inflammatory and anti-tumor activities, due, in part, to inhibition of NF-kappaB activity. | Isoflavones | nuclear factor kappa B subunit 1 | Homo sapiens |
| 3 | However, the structural moiety of isoflavones responsible for the inhibition of NF-kappaB is not clearly understood. | Isoflavones | nuclear factor kappa B subunit 1 | Homo sapiens |
| 4 | In this work, structure-activity relationships of isoflavone derivatives were examined with regard to NF-kappaB inhibition, using CoMFA and CoMSIA. | Isoflavones | nuclear factor kappa B subunit 1 | Homo sapiens |