Title : N-acetylcysteine counteracts oxidative stress and prevents hCG-induced apoptosis in rat Leydig cells through down regulation of caspase-8 and JNK.

Pub. Date : 2010 Oct

PMID : 20824644






3 Functional Relationships(s)
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1 N-acetylcysteine counteracts oxidative stress and prevents hCG-induced apoptosis in rat Leydig cells through down regulation of caspase-8 and JNK. Acetylcysteine mitogen-activated protein kinase 8 Rattus norvegicus
2 NAC treatment induced down-regulation of upstream JNK/pJNK and down-stream caspase-3 in the target cells. Acetylcysteine mitogen-activated protein kinase 8 Rattus norvegicus
3 Taken together, the above findings indicate that NAC counteracted the oxidative stress in Leydig cells induced as a result of repeated hCG stimulation, and inhibited apoptosis by mainly regulating the extrinsic and JNK pathways of metazoan apoptosis. Acetylcysteine mitogen-activated protein kinase 8 Rattus norvegicus