Title : Effect of δ-tocotrienol on melanin content and enzymes for melanin synthesis in mouse melanoma cells.

Pub. Date : 2010

PMID : 20823559






2 Functional Relationships(s)
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1 Tyrosinase activity, amounts of tyrosinase and TRP-1 decreased dependent on dose : by 50 (25 microM delta-tocotrienol) to 75% (50 microM), 20 to 45% and 42 to 82% at 48 h, and by 25 to 50%, 75 to 80% and 78 to 77% at 72 h, respectively. tocotrienol, delta tyrosinase Mus musculus
2 From these findings, delta-tocotrienol at up to 50 microM dose-dependently caused a reduction in melanin content by the decrease of TRP-1 and TRP-2 as well as tyrosinase, and no cytotoxicity. tocotrienol, delta tyrosinase Mus musculus