Title : The effect of infliximab plus methotrexate on the modulation of inflammatory disease markers in juvenile idiopathic arthritis: analyses from a randomized, placebo-controlled trial.

Pub. Date : 2010 Sep 7

PMID : 20822542






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1 The decreases from baseline to week 52 in IL-6, ICAM-1, VEGF, MMP-3, and CRP and increases in IL-12p40 levels were larger in patients receiving placebo infliximab 6 mg/kg +MTX versus infliximab 3 mg/kg + MTX treatment. Methotrexate matrix metallopeptidase 3 Homo sapiens
2 CONCLUSION: Infliximab + MTX attenuated several inflammatory markers in patients with JIA; larger decreases in ICAM-1, MMP-3, and CRP levels were observed in ACR-Pedi-30 responders versus nonresponders. Methotrexate matrix metallopeptidase 3 Homo sapiens