Title : Chemistry and pharmacological characterization of novel nitrogen analogues of AMOP-H-OH (Sazetidine-A, 6-[5-(azetidin-2-ylmethoxy)pyridin-3-yl]hex-5-yn-1-ol) as α4β2-nicotinic acetylcholine receptor-selective partial agonists.

Pub. Date : 2010 Oct 14

PMID : 20822184






1 Functional Relationships(s)
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1 Structure-activity relationship (SAR) analyses suggest that the introduction of additional substituents to the amino group present on the pyridine ring of the N-demethylated analogue of compound 17 can provide potent alpha4beta2-nAChR-selective ligands for possible use in treatment of neurological and psychiatric disorders including depression. pyridine cholinergic receptor nicotinic alpha 4 subunit Homo sapiens