Pub. Date : 2010 Nov 1
PMID : 20818182
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Actinomycin D synergistically enhances the efficacy of the BH3 mimetic ABT-737 by downregulating Mcl-1 expression. | 2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid | MCL1 apoptosis regulator, BCL2 family member | Homo sapiens |
| 2 | Like actinomycin D treatment, knocking down Mcl-1 expression greatly sensitized tumor cells to ABT-737, and Mcl-1 over-expression abrogated the cytotoxic effect induced by ABT-737 and actinomycin D. | 2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid | MCL1 apoptosis regulator, BCL2 family member | Homo sapiens |
| 3 | Like actinomycin D treatment, knocking down Mcl-1 expression greatly sensitized tumor cells to ABT-737, and Mcl-1 over-expression abrogated the cytotoxic effect induced by ABT-737 and actinomycin D. | 2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid | MCL1 apoptosis regulator, BCL2 family member | Homo sapiens |